The cut points were derived from a combination of two sets of data. First, based on over 27,000 samples analyzed at OmegaQuant Analytics over the last few years, they have an idea of the distribution of the Trans Fat Index in the US population. Second, they used published data from Sun et al. (Circulation 2007;115:1858-1865) in the Nurses’ Health Study. These researchers measured levels of industrially-produced trans fats in red blood cell membranes and related those levels to risk for cardiovascular events. They found a statistically significant, direct relationship between the Trans Fat Index and heart disease – higher levels were associated with higher risk. Those women in the highest 25% of the population (4th quartile) were 2.8x as likely to have a cardiac event as women in the lowest quartile.
Based on these two data sets, OmegaQuant chose the lowest quartile in the Sun paper (1.0%) as the upper limit of the Desirable level, and the highest quartile (1.65%) as the beginning of the lower limit of the Undesirable category. Individuals between 1% and 1.65% would be considered in the Intermediate zone. In the 27,000 sample data set from OmegaQuant, only about 13% of the population had a Desirable Trans Fat Index; 65% of the population had an Intermediate score; and 22% of the population was in the Undesirable range.
Since more data is still needed to really know what the “healthiest” level of trans fats would be, it is more important for the consumer to see a decrease in his/her Trans Fat Index after making healthier dietary choices than for the consumer to be in a specific risk group. In other words, lowering the Trans Fat Index from whatever level it is at the start shows good progress and would be expected to lower heart disease risk.